Evan Peters, Kathy Bates, Billie Lourd, Finn Wittrock, Lily Rabe, Adina Porter, Leslie Grossman and Angelica Ross are also set to star.
Murphy made the announcement by uploading a video of a credits sequence set to the song “Dead of Night” by Orville Peck.
Culkin is a newcomer to “American Horror Story” while the others are series mainstays. Paulson and Peters were notably not involved with Season 9 after appearing in every previous season.
“American Horror Story,” which premiered in 2011, is created by Murphy and Brad Falchuk. Each season has been centered around a new horror theme and setting.
FX renewed the series through Season 13 in January.